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| Michelle Price Judge (University of Connecticut), Dr. Holiday Durham (Louisiana State University), Michele Mckelvey (University of Connecticut), and Dr. Carol Lammi-Keefe (Louisiana State University) were coauthors on this paper. This study was funded by the Patrick and Catherine Weldon Donaghue Medical Research Foundation. Researchers report that those with mild/moderate Alzhimer's Disease symptoms who received omega-3 DHA fatty acid (docosahexaenoic acid) over an 18-month period experienced the same rates of cognitive and functional decline as those on a placebo.
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Their study has been published in today's issue of JAMA (Journal of the American Medical Association) which focuses on aging this week. The scientists had been hoping for encouraging results because fish oils have been linked to a lower risk of dementia and cognitive decline. Cognition refers to the process of being aware, thinking, knowing, judging and learning. Cognitive decline refers to lower awareness, knowing, judging, learning and thinking. People with Alzheimer's disease experience progressive cognitive decline. of Oregon Health and Science University and the Portland VA Medical Center, Portland, Ore. said: Several studies have found that consumption of fish, the primary dietary source of omega-3 fatty acids, is associated with a reduced risk of cognitive decline or dementia. Some studies have found that consumption of DHA, but not other omega-3 fatty acids, is associated with a reduced risk of Alzheimer disease. However, those studies did not control who was given DHA.
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| This finding is of significance as it may provide some new insights into the mechanism of this highly fatal disease, said lead author Dominique Michaud, assistant professor of epidemiology at HSPH. Periodontal disease is caused by bacterial infection and inflammation of the gums that over time causes loss of bone that supports the teeth; tooth loss is a consequence of severe periodontal disease. Two previous studies had found a link between tooth loss or periodontitis and pancreatic cancer, but one consisted of all smokers and the other did not control for smoking in the analysis, and therefore no firm conclusions could be drawn from these studies. Data for the new study came from the Health Professionals Follow-Up Study, which began in 1986 and includes 51,529 U. Participants respond to questionnaires about their health every two years. After analyzing the data, the researchers confirmed 216 cases of pancreatic cancer between 1986 and 2002; of those, 67 reported periodontal disease. The results showed that, after adjusting for age, smoking, diabetes, body mass index and a number of other factors, men with periodontal disease had a 63% higher risk of developing pancreatic cancer compared to those reporting no periodontal disease. Most convincing was our finding that never-smokers had a two-fold increase in risk of pancreatic cancer, said Michaud. One possible explanation for the results is that inflammation from periodontal disease may promote cancer of the pancreas.
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Individuals with periodontal disease have elevated serum biomarkers of systemic inflammation, such as C-reactive protein, and these may somehow contribute to the promotion of cancer cells, she said. Another explanation, according to Michaud, is that periodontal disease could lead to increased pancreatic carcinogenesis because individuals with periodontal disease have higher levels of oral bacteria and higher levels of nitrosamines, which are carcinogens, in their oral cavity. Prior studies have shown that nitrosamines and gastric acidity may play a role in pancreatic cancer. Michaud, senior author Charles Fuchs, a gastrointestinal oncologist at Dana-Farber, and their colleagues believe that further studies should be done to investigate the role of inflammation from periodontal disease in pancreatic cancer.
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| SheaftPeash | Дата: Суббота, 07.09.2013, 01:19 | Сообщение # 19 |
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| Stratego is a board game for two players on a 10x10 square board. Each player controls 40 pieces representing individual officers and soldiers in an army. The objective of the game is to find and capture the opponent's Flag, or to capture so many enemy pieces that the opponent cannot make any further moves. Players cannot see the ranks of one another's pieces, so disinformation and discovery are important facets to gameplay.
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| SaureSertgog | Дата: Среда, 11.09.2013, 14:54 | Сообщение # 20 |
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| The closeness effect was heightened for pairs in which the caregiver was a spouse, as opposed to an adult child or in-law. Patients with close spouses declined the slowest overall, with scores on the MMSE showing changes over time similar to patients participating in recent clinical trials for FDA-approved Alzheimer's drugs called acetylcholinesterase inhibitors. We've shown that the benefits of having a close caregiver, especially a spouse, may be substantial. The difference in cognitive and functional decline over time between close and not-as-close pairs can mean the difference between staying at home or going to a nursing facility, says Lyketsos. The study was funded by grants from the National Institute on Aging, one of the National Institutes of Health.
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